Study title

Effect of SLT on Outflow Facility

Type

Prospective

Number of patients

40

Primery investigator

Sheng Lim

Secondary investigators

 

Contact informaion

shenglim@gmail.com

Place

St. Thomas' Hospital

Town

London

Country

England

Start date

feb-06

Expected completion date

Dec-06

Expected publication date

The aim of this project is to determine the effect of SLT on the trabecular outflow facility in human eyes.

Purpose

The study eye of each patient will have the intraocular pressure and outflow facility measured on 3 occasions: On the day prior to the SLT treatment (Baseline), at 1 month and at 3 months.
Intraocular Pressure: Intraocular pressure will be measured with a Goldmann’s applanation tonometer, using a topical anesthetic, and fluorescein as the disclosing agent.  The right eye will be measured first, followed by measurement of the left.  This sequence will be repeated three times.  The three measurements for each eye will be averaged and reported as intraocular pressure.
Tonographic Outflow Facility: The facility of outflow will be measured from the rate of decay of intraocular pressure in the supine position during application of a recording Schiötz or pneumo tonometer over a period of 4 minutes.  The “R” values of the curve at every 30 second time point will be manually entered into the McLaren tonography computer program.  The program fits a second degree polynomial by least squares to the nine data points and determine the best fit values for time 0 and time 4 minutes by extrapolation.  These initial and final values of the tonometer scale reading will be used to look up the value for the facility of outflow using the 1955 scale approved by the Committee on Standardization of Tonometers.

method

 

Preliminary Results

 

Conclusion

Study started in September
Effect of SLT on Outflow Facility