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Study title |
Influence of selective laser trabeculoplasty on diurnal intraocular fluctuation in primary open-angle glaucoma |
Type |
Prospective |
Number of patients |
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Primery investigator |
Gábor Holló, Péter Kóthy, Márta Tóth |
Secondary investigators |
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Contact informaion |
mailto:hg@mail.tvnet.hu |
Place |
Department of Ophthalmology, Semmelweis University |
Town |
Budapest |
Country |
Hongaria |
Start date |
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Expected completion date |
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Expected publication date |
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Purpose |
To investigate the influence of selective laser trabeculoplasty (SLT) on mean diurnal intraocular pressure (IOP) and diurnal IOP fluctuation in primary open-angle glaucoma (POAG). |
method |
In this prospective study 26 eyes of 13 Caucasian POAG patients with no previous laser or incisional surgery underwent a 4-week washout period before obtaining baseline diurnal IOP curve. IOP measurements were performed at 12.00 am, 4.00 pm, 8.00 pm, 24.00 pm, 4.00 am and 8.00 am with Goldmann applanation tonometry in sitting position. Standard 360 degree SLT was performed in all eyes, followed by 7 days of topical fluoromethalone or dexamethasone treatment. Safety visits were performed at one week and one month after treatment. The IOP curve was repeated after 3 and 6 months in eyes with no IOP lowering medication. IOP lowering medication was indicated if mean diurnal IOP was higher than 22 mmHg or any single IOP value exceeded 26 mmHg at any visit. |
Preliminary Results |
Though in this pilot study no eyes showed a mean diurnal IOP reduction of 20% after treatment, SLT resulted in a significant decrease of the mean diurnal IOP and the diurnal IOP fluctuation in patients with POAG. |
Conclusion |
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Influence of selective laser trabeculoplasty on diurnal intraocular fluctuation
